Journal Papers

2018

Kinetic models of metabolism that consider alternative steady-state solutions of intracellular fluxes and concentrations

T. E. Hameri; G. Fengos; M. Ataman; L. Miskovic; V. Hatzimanikatis

Metabolic Engineering. 2018-10-26.

DOI : 10.1016/j.ymben.2018.10.005.

Discovery and Evaluation of Biosynthetic Pathways for the Production of Five Methyl Ethyl Ketone Precursors

M. Tokic; N. Hadadi; M. Ataman; D. Neves; B. E. Ebert et al.

ACS Synthetic Biology. 2018-07-18.

DOI : 10.1021/acssynbio.8b00049.

pyTFA and matTFA: a Python package and a Matlab toolbox for Thermodynamics-based Flux Analysis

P. Salvy; G. Fengos; M. Ataman; T. Pathier; K. C. Soh et al.

Bioinformatics. 2018-07-02.

DOI : 10.1093/bioinformatics/bty499.

Efficient cleavage of aryl ether C–O linkages by Rh–Ni and Ru–Ni nanoscale catalysts operating in water

S. Bulut; S. Siankevich; A. P. van Muyden; D. T. L. Alexander; G. Savoglidis et al.

Chemical Science. 2018.

DOI : 10.1039/C8SC00742J.

2017

Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions

L. C. Bryan; D. R. Weilandt; A. L. Bachmann; S. Kilic; C. C. Lechner et al.

Nucleic Acids Research. 2017.

DOI : 10.1093/nar/gkx697.

redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models

M. Ataman; D. F. H. Gardiol; G. Fengos; V. Hatzimanikatis

Plos Computational Biology. 2017.

DOI : 10.1371/journal.pcbi.1005444.

lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites

M. Ataman; V. Hatzimanikatis

Plos Computational Biology. 2017.

DOI : 10.1371/journal.pcbi.1005513.

Exploring biochemical pathways for mono-ethylene glycol (MEG) synthesis from synthesis gas

M. A. Islam; N. Hadadi; M. Ataman; V. Hatzimanikatis; G. Stephanopoulos

Metabolic Engineering. 2017.

DOI : 10.1016/j.ymben.2017.04.005.

Mechanistic Modeling of Genetic Circuits for ArsR Arsenic Regulation

Y. Berset; D. Merulla; A. Joublin; V. Hatzimanikatis; J. R. Van Der Meer

Acs Synthetic Biology. 2017.

DOI : 10.1021/acs.synbio.6b00364.

On Lewis acidity/basicity and hydrogen bonding in the equation-of-state approach

C. Panayiotou; S. Mastrogeorgopoulos; V. Hatzimanikatis

Journal Of Chemical Thermodynamics. 2017.

DOI : 10.1016/j.jct.2017.02.003.

Redefining solubility parameters: Bulk and surface properties from unified molecular descriptors

C. Panayiotou; S. Mastrogeorgopoulos; D. Aslanidou; M. Avgidou; V. Hatzimanikatis

Journal Of Chemical Thermodynamics. 2017.

DOI : 10.1016/j.jct.2017.03.035.

A Design-Build-Test cycle using modeling and experiments reveals interdependencies between upper glycolysis and xylose uptake in recombinant S. cerevisiae and improves predictive capabilities of large-scale kinetic models

L. Miskovic; S. Alff-Tuomala; K. C. Soh; D. Barth; L. Salusjärvi et al.

Biotechology for Biofuels. 2017.

DOI : 10.1186/s13068-017-0838-5.

Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks

A. Kiparissides; V. Hatzimanikatis

Metabolic Engineering. 2017.

DOI : 10.1016/j.ymben.2016.11.006.

Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

A. Chiappino Pepe; S. Tymoshenko; M. Ataman; D. Soldati-Favre; V. Hatzimanikatis

PLoS Computational Biology. 2017.

DOI : 10.1371/journal.pcbi.1005397.

Reconstruction of biological pathways and metabolic networks from in silico labeled metabolites

N. Hadadi; J. Hafner; K. C. Soh; V. Hatzimanikatis

Biotechnology Journal. 2017.

DOI : 10.1002/biot.201600464.

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

A. Chiappino Pepe; V. K. Pandey; M. Ataman; V. Hatzimanikatis

Current Opinion in Systems Biology. 2017.

DOI : 10.1016/j.coisb.2017.01.007.

2016

Molecular thermodynamics of metabolism: hydration quantities and the equation-of-state approach

C. Panayiotou; S. Mastrogeorgopoulos; M. Ataman; N. Hadadi; V. Hatzimanikatis

Physical Chemistry Chemical Physics -Cambridge- Royal Society of Chemistry. 2016.

DOI : 10.1039/C6CP06281D.

Principles of Systems Biology, No. 11

G. Wayne; A. Graves; D. Hassabis; S. Saha; C. A. Weber et al.

Cell Systems. 2016.

Molecular thermodynamics of metabolism: hydration quantities and the equation-of-state approach

C. Panayiotou; S. Mastrogeorgopoulos; M. Ataman; N. Hadadi; V. Hatzimanikatis

Physical Chemistry Chemical Physics. 2016.

DOI : 10.1039/c6cp06281d.

ATLAS of Biochemistry: A Repository of All Possible Biochemical Reactions for Synthetic Biology and Metabolic Engineering Studies

N. Hadadi; J. Hafner; A. Shajkofci; A. Zisaki; V. Hatzimanikatis

Acs Synthetic Biology. 2016.

DOI : 10.1021/acssynbio.6b00054.

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

J. Pinto Vieira; J. Racle; V. Hatzimanikatis

Biophysical Journal. 2016.

DOI : 10.1016/j.bpj.2016.04.004.

Sustainability assessment of succinic acid production technologies from biomass using metabolic engineering

M. Morales; M. Ataman; S. Badr; S. Linster; I. Kourlimpinis et al.

Energy & Environmental Science. 2016.

DOI : 10.1039/c6ee00634e.

Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models

A. Isakova; Y. Berset; V. Hatzimanikatis; B. Deplancke

Journal Of Biological Chemistry. 2016.

DOI : 10.1074/jbc.M115.691154.

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

G. Savoglidis; A. X. D. S. Dos Santos; I. Riezman; P. Angelino; H. Riezman et al.

Metabolic Engineering. 2016.

DOI : 10.1016/j.ymben.2016.04.002.

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

J. Vieira; J. Racle; V. Hatzimanikatis

Biophysical Journal. 2016.

DOI : 10.1016/j.bpj.2016.04.004.

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

L. A. Bultet; J. Aguilar Rodriguez; C. H. Ahrens; E. L. Ahrne; N. Ai et al.

Nucleic Acids Research. 2016.

DOI : 10.1093/nar/gkv1310.

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

T. Dallavilla; L. Abrami; P. A. Sandoz; G. Savoglidis; V. Hatzimanikatis et al.

PLOS Computational Biology. 2016.

DOI : 10.1371/journal.pcbi.1004774.

Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

S. Andreozzi; A. Charkrabarti; K. C. Soh; A. Burgard; T.-H. Yang et al.

Metabolic Engineering. 2016.

DOI : 10.1016/j.ymben.2016.01.009.

iSCHRUNK – In Silico Approach to Characterization and Reduction of Uncertainty in the Kinetic Models of Genome-scale Metabolic Networks

S. Andreozzi; L. Miskovic; V. Hatzimanikatis

Metabolic Engineering. 2016.

DOI : 10.1016/j.ymben.2015.10.002.

2015

Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways

N. Hadadi; V. Hatzimanikatis

Current Opinion In Chemical Biology. 2015.

DOI : 10.1016/j.cbpa.2015.06.025.

Do genome-scale models need exact solvers or clearer standards?

A. Ebrahim; E. Almaas; E. Bauer; A. Bordbar; A. P. Burgard et al.

Molecular Systems Biology. 2015.

DOI : 10.15252/msb.20156157.

Heading in the right direction: thermodynamics-based network analysis and pathway engineering

M. Ataman; V. Hatzimanikatis

Current Opinion in Biotechnology. 2015.

DOI : 10.1016/j.copbio.2015.08.021.

Integrative approaches for signalling and metabolic networks

V. Hatzimanikatis; J. Saez-Rodriguez

Integrative Biology. 2015.

DOI : 10.1039/c5ib90030a.

Solvation quantities from a COSMO-RS equation of state

C. Panayiotou; I. Tsivintzelis; D. Aslanidou; V. Hatzimanikatis

Journal Of Chemical Thermodynamics. 2015.

DOI : 10.1016/j.jct.2015.07.011.

Rites of passage: requirements and standards for building kinetic models of metabolic phenotypes

L. Miskovic; M. Tokic; G. Fengos; V. Hatzimanikatis

Current Opinion in Biotechnology. 2015.

DOI : 10.1016/j.copbio.2015.08.019.

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

J. Racle; A. J. Stefaniuk; V. Hatzimanikatis

The Journal of Chemical Physics. 2015.

DOI : 10.1063/1.4926536.

Molecular thermodynamics of metabolism: quantum thermochemical calculations for key metabolites

N. Hadadi; M. Ataman; V. Hatzimanikatis; C. Panayiotou

Physical Chemistry Chemical Physics. 2015.

DOI : 10.1039/c4cp05825a.

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

S. Tymoshenko; R. D. Oppenheim; R. Agren; J. Nielsen; D. Soldati-Favre et al.

PLOS Computational Biology. 2015.

DOI : 10.1371/journal.pcbi.1004261.

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

A. Zisaki; L. Miskovic; V. Hatzimanikatis

Current Pharmaceutical Design. 2015.

2014

Kinetic models in industrial biotechnology - Improving cell factory performance

J. Almquist; M. Cvijovic; V. Hatzimanikatis; J. Nielsen; M. Jirstrand

Metabolic Engineering. 2014.

DOI : 10.1016/j.ymben.2014.03.007.

A computational framework for integration of lipidomics data into metabolic pathways

N. Hadadi; K. Cher Soh; M. Seijo; A. Zisaki; X. Guan et al.

Metabolic engineering. 2014.

DOI : 10.1016/j.ymben.2013.12.007.

2013

Metabolic modeling in biotechnology and medical research

D. Mattanovich; V. Hatzimanikatis

Biotechnology Journal. 2013.

DOI : 10.1002/biot.201300378.

A Novel Pulse-Chase SILAC Strategy Measures Changes in Protein Decay and Synthesis Rates Induced by Perturbation of Proteostasis with an Hsp90 Inhibitor

I. Fierro-Monti; J. Racle; C. Hernandez; P. Waridel; V. Hatzimanikatis et al.

Plos One. 2013.

DOI : 10.1371/journal.pone.0080423.

A Genome-Scale Integration and Analysis of Lactococcus lactis Translation Data

J. Racle; F. Picard; L. Girbal; M. Cocaign-Bousquet; V. Hatzimanikatis

Plos Computational Biology. 2013.

DOI : 10.1371/journal.pcbi.1003240.

Tunable reporter signal production in feedback-uncoupled arsenic bioreporters

D. Merulla; V. Hatzimanikatis; J. R. Van Der Meer

Microbial Biotechnology. 2013.

DOI : 10.1111/1751-7915.12031.

Mechanistically Consistent Reduced Models of Synthetic Gene Networks

L. Mier-Y-Teran-Romero; M. Silber; V. Hatzimanikatis

Biophysical Journal. 2013.

DOI : 10.1016/j.bpj.2013.03.031.

Functional genomics of Plasmodium falciparum using metabolic modelling and analysis

S. Tymoshenko; R. Oppenheim; D. Soldati-Favre; V. Hatzimanikatis

Briefings in Functional Genomics. 2013.

DOI : 10.1093/bfgp/elt017.

Towards kinetic modeling of genome-scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiology constraints

A. Chakrabarti; L. Miskovic; K. C. Soh; V. Hatzimanikatis

Biotechnology Journal. 2013.

DOI : 10.1002/biot.201300091.

2012

Exploration of trade-offs between steady-state and dynamic properties in signaling cycles

A. Radivojevic; B. Chachuat; D. Bonvin; V. Hatzimanikatis

Physical Biology. 2012.

DOI : 10.1088/1478-3975/9/4/045010.

A computational framework for the design of optimal protein synthesis

J. Racle; J. Overney; V. Hatzimanikatis

Biotechnology and Bioengineering. 2012.

DOI : 10.1002/bit.24463.

Integrating computational methods to retrofit enzymes to synthetic pathways

E. Brunk; M. Neri; I. Tavernelli; V. Hatzimanikatis; U. Rothlisberger

Biotechnology and Bioengineering. 2012.

DOI : 10.1002/bit.23334.

2011

Systems biology

R. Kishony; V. Hatzimanikatis

Current Opinion In Biotechnology. 2011.

DOI : 10.1016/j.copbio.2011.06.001.

From network models to network responses: integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks

K. C. Soh; L. Miskovic; V. Hatzimanikatis

FEMS Yeast Research. 2011.

DOI : 10.1111/j.1567-1364.2011.00771.x.

2010

In silico feasibility of novel biodegradation pathways for 1,2,4-trichlorobenzene

S. D. Finley; L. J. Broadbelt; V. Hatzimanikatis

Bmc Systems Biology. 2010.

DOI : 10.1186/1752-0509-4-7.

Discovery and Analysis of Novel Metabolic Pathways for the Biosynthesis of Industrial Chemicals: 3-Hydroxypropanoate

C. S. Henry; L. J. Broadbelt; V. Hatzimanikatis

Biotechnology And Bioengineering. 2010.

DOI : 10.1002/bit.22673.

The Origins of Time-Delay in Template Biopolymerization Processes

L. Mier-y-Teran-Romero; M. Silber; V. Hatzimanikatis

Plos Computational Biology. 2010.

DOI : 10.1371/journal.pcbi.1000726.

Thermodynamic Calculations for Biochemical Transport and Reaction Processes in Metabolic Networks

S. J. Jol; A. Kuemmel; V. Hatzimanikatis; D. A. Beard; M. Heinemann

Biophysical Journal. 2010.

DOI : 10.1016/j.bpj.2010.09.043.

Manipulating redox and ATP balancing for improved production of succinate in E. coli

A. Singh; K. C. Soh; V. Hatzimanikatis; R. T. Gill

Metabolic Engineering. 2010.

DOI : 10.1016/j.ymben.2010.10.006.

Modeling of uncertainties in biochemical reactions

L. Miskovic; V. Hatzimanikatis

Biotechnology and Bioengineering. 2010.

DOI : 10.1002/bit.22932.

DREAMS of metabolism

K. C. Soh; V. Hatzimanikatis

Trends in Biotechnology. 2010.

DOI : 10.1016/j.tibtech.2010.07.002.

Network thermodynamics in the post-genomic era

K. C. Soh; V. Hatzimanikatis

Current opinion in microbiology. 2010.

DOI : 10.1016/j.mib.2010.03.001.

Production of biofuels and biochemicals: in need of an ORACLE

L. Miskovic; V. Hatzimanikatis

Trends in Biotechnology. 2010.

DOI : 10.1016/j.tibtech.2010.05.003.

2009

Thermodynamic Analysis of Biodegradation Pathways

S. D. Finley; L. J. Broadbelt; V. Hatzimanikatis

Biotechnology And Bioengineering. 2009.

DOI : 10.1002/bit.22285.

Computational Framework for Predictive Biodegradation

S. D. Finley; L. J. Broadbelt; V. Hatzimanikatis

Biotechnology And Bioengineering. 2009.

DOI : 10.1002/bit.22489.

2008

Group contribution method for thermodynamic analysis of complex metabolic networks

M. D. Jankowski; C. S. Henry; L. J. Broadbelt; V. Hatzimanikatis

Biophysical Journal. 2008.

DOI : 10.1529/biophysj.107.124784.

Effects of codon distributions and tRNA competition on protein translation

H. Zouridis; V. Hatzimanikatis

Biophysical Journal. 2008.

DOI : 10.1529/biophysj.107.126128.

2007

A Model for Protein Translation: Polysome Self-Organization Leads to Maximum Protein Synthesis Rates

H. Zouridis; V. Hatzimanikatis

Biophysical Journal. 2007.

DOI : 10.1529/biophysj.106.087825.

Thermodynamics-Based Metabolic Flux Analysis

C. S. Henry; L. J. Broadbelt; V. Hatzimanikatis

Biophysical Journal. 2007.

A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression data

R. Thomas; C. J. Paredes; S. Mehrotra; V. Hatzimanikatis; E. T. Papoutsakis

BMC Bioinformatics. 2007.

2006

Analysis of the Maximum Theoretical Yield for the Synthesis of Erythromycin Precursors in Escherichia coli

J. Gonzalez-Lergier; L. J. Broadbelt; V. Hatzimanikatis

Biotechnology and Bioengineering. 2006.

DOI : 10.1002/bit.20925.

Metabolic engineering under uncertainty. I: Framework development

L. Wang; V. Hatzimanikatis

Metabolic Engineering. 2006.

Metabolic engineering under uncertainty-II: Analysis of yeast metabolism

L. Wang; V. Hatzimanikatis

Metabolic Engineering. 2006.

Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo

T. R. Rieger; R. I. Morimoto; V. Hatzimanikatis

Biophysical Journal. 2006.

An algorithmic framework for genome-wide modeling and analysis of translation networks

A. Mehra; V. Hatzimanikatis

Biophysical Journal. 2006.

Genome-scale thermodynamic analysis of Escherichia coli metabolism

C. S. Henry; M. D. Jankowski; L. J. Broadbelt; V. Hatzimanikatis

Biophysical Journal. 2006.

2005

Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter

T. R. Rieger; R. I. Morimoto; V. Hatzimanikatis

Biophysical Journal. 2005.

Preface

C. Maranas; V. Hatzimanikatis

Computers & Chemical Engineering. 2005.

DOI : 10.1016/j.compchemeng.2004.08.008.

Exploring the diversity of complex metabolic networks

V. Hatzimanikatis; C. Li; J. A. Ionita; C. S. Henry; M. D. Jankowski et al.

Bioinformatics. 2005.

Theoretical Considerations and Computational Analysis of the Complexity in Polyketide Synthesis Pathways

J. Gonzalez-Lergier; L. J. Broadbelt; V. Hatzimanikatis

Journal of the American Chemical Society. 2005.

DOI : 10.1021/ja051586y.

2004

Metabolic control analysis under uncertainty: Framework development and case studies

L. Wang; I. Birol; V. Hatzimanikatis

Biophysical Journal. 2004.

A model-based optimization framework for the inference on gene regulatory networks from DNA array data

R. Thomas; S. Mehrotra; E. T. Papoutsakis; V. Hatzimanikatis

Bioinformatics. 2004.

DOI : 10.1093/bioinformatics/bth389.

Computational discovery of biochemical routes to specialty chemicals

C. Li; C. S. Henry; M. D. Jankowski; J. A. Ionita; V. Hatzimanikatis et al.

Chemical Engineering Science. 2004.

Metabolic networks: enzyme function and metabolite structure

V. Hatzimanikatis; C. Li; J. A. Ionita; L. J. Broadbelt

Current Opinion in Structural Biology. 2004.

DOI : 10.1016/j.sbi.2004.04.004.

2003

Insights into the relation between mRNA and protein expression patterns: I. Theoretical considerations

A. Mehra; K. H. Lee; V. Hatzimanikatis

Biotechnology and Bioengineering. 2003.

DOI : 10.1002/bit.10860.

Insights into the relation between mRNA and protein expression patterns: II. Experimental observations in Escherichia coli

P. S. Lee; L. B. Shaw; L. H. Choe; A. Mehra; V. Hatzimanikatis et al.

Biotechnology and Bioengineering. 2003.

2002

Jay Bailey as mentor-the students' perspective

K. F. Reardon; K. H. Lee; K. D. Wittrup; V. Hatzimanikatis

Biotechnology and Bioengineering. 2002.

DOI : 10.1002/bit.10402.

Biochemical engineering

K. H. Lee; V. Hatzimanikatis

Current Opinion in Biotechnology. 2002.

A memorial review of Jay Bailey's contribution in prokaryotic metabolic engineering

V. Hatzimanikatis; J. C. Liao

Biotechnology and Bioengineering. 2002.

DOI : 10.1002/bit.10406.

Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes

J. E. Bailey; A. Sburlati; V. Hatzimanikatis; K. Lee; W. A. Renner et al.

Biotechnology and Bioengineering. 2002.

DOI : 10.1002/bit.10441.

2000

Bioinformatics, genomics, and the chemical engineer: a perspective

V. Hatzimanikatis; D. Collins; S. Lawrence; S. Browning; K. H. Lee

Chemical Engineering Education. 2000.

Bioinformatics and functional genomics: challenges and opportunities

V. Hatzimanikatis

AIChE Journal. 2000.

1999

Proteomics: Theoretical and Experimental Considerations

V. Hatzimanikatis; L. H. Choe; K. H. Lee

Biotechnology Progress. 1999.

DOI : 10.1021/bp990004b.

Dynamical analysis of gene networks requires both mRNA and protein expression information

V. Hatzimanikatis; K. H. Lee

Metabolic Engineering. 1999.

Modelling molecular mechanisms within their cellular environment

V. Hatzimanikatis; J. E. Bailey

Journal of Biotechnology. 1999.

DOI : 10.1016/S0168-1656(99)00032-2.

Nonlinear metabolic control analysis

V. Hatzimanikatis

Metabolic Engineering. 1999.

A mathematical description of regulation of the G1-S transition of the mammalian cell cycle

V. Hatzimanikatis; K. H. Lee; J. E. Bailey

Biotechnology and Bioengineering. 1999.

DOI : 10.1002/(SICI)1097-0290(19991220)65:6<631::AID-BIT3>3.0.CO;2-7.

1998

Application of mathematical tools for metabolic design of microbial ethanol production

V. Hatzimanikatis; M. Emmerling; U. Sauer; J. E. Bailey

Biotechnology and Bioengineering. 1998.

DOI : 10.1002/(SICI)1097-0290(19980420)58:2/3<154::AID-BIT7>3.0.CO;2-K.

1997

The AlkB monooxygenase of Pseudomonas oleovorans. Synthesis, stability, and level in recombinant Escherichia coli and the native host

I. E. Staijen; V. Hatzimanikatis; B. Withold

European Journal of Biochemistry. 1997.

Metabolic fluxes in riboflavin-producing Bacillus subtilis

U. Sauer; V. Hatzimanikatis; J. E. Bailey; M. Hochuli; T. Szyperski et al.

Nature Biotechnology. 1997.

DOI : 10.1038/nbt0597-448.

Effects of spatiotemporal variations on metabolic control: approximate analysis using (log)linear kinetic models

V. Hatzimanikatis; J. E. Bailey

Biotechnology and Bioengineering. 1997.

DOI : 10.1002/(SICI)1097-0290(19970420)54:2<91::AID-BIT1>3.0.CO;2-Q.

Studies on glycolysis - I. Multiple steady states in bacterial glycolysis

V. Hatzimanikatis; J. E. Bailey

Chemical Engineering Science. 1997.

DOI : 10.1016/S0009-2509(97)00074-2.

Metabolic consequences of phosphotransferase (PTS) mutation in a phenylalanine-producing recombinant Escherichia coli

R. Chen; V. Hatzimanikatis; W. M. G. J. Yap; P. W. Postma; J. E. Bailey

Biotechnology Progress. 1997.

DOI : 10.1021/bp970060h.

1996

Effect of Vitreoscilla hemoglobin dosage on microaerobic Escherichia coli carbon and energy metabolism

P. S. Tsai; V. Hatzimanikatis; J. E. Bailey

Biotechnology and Bioengineering. 1996.

Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis

U. Sauer; V. Hatzimanikatis; H.-P. Hohmann; M. Manneberg; A. P. G. M. van Loon et al.

Applied and Environmental Microbiology. 1996.

Analysis and design of metabolic reaction networks via mixed-integer linear optimization

V. Hatzimanikatis; C. A. Floudas; J. E. Bailey

AIChE Journal. 1996.

DOI : 10.1002/aic.690420509.

Optimization of regulatory architectures in metabolic reaction networks

V. Hatzimanikatis; C. A. Floudas; J. E. Bailey

Biotechnology and Bioengineering. 1996.

DOI : 10.1002/(SICI)1097-0290(19961120)52:4<485::AID-BIT4>3.0.CO;2-L.

MCA has more to say

V. Hatzimanikatis; J. E. Bailey

Journal of Theoretical Biology. 1996.

DOI : 10.1006/jtbi.1996.0160.

Metabolic flux analysis of hybridoma cells in different culture media using mass balances

H. P. J. Bonarius; V. Hatzimanikatis; K. P. H. Meesters; C. D. de Gooijer; G. Schmid et al.

Biotechnology and Bioengineering. 1996.

DOI : 10.1002/(SICI)1097-0290(19960505)50:3<299::AID-BIT9>3.0.CO;2-B.

Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes

J. E. Bailey; A. Sburlati; V. Hatzimanikatis; K. Lee; W. A. Renner et al.

Biotechnology and Bioengineering. 1996.

DOI : 10.1002/(SICI)1097-0290(19961005)52:1<109::AID-BIT11>3.0.CO;2-J.

1995

A Mathematical Model for the G1/S Transition of the Mammalian Cell Cycle

V. Hatzimanikatis; K. Lee; W. Renner; J. Bailey

Biotechnology Letters. 1995.

Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium

W. A. Renner; L. H. Lee; V. Hatzimanikatis; J. E. Bailey; H. M. Eppenberger

Biotechnology and Bioengineering. 1995.

DOI : 10.1002/bit.260470409.

1993

A method for pulsed periodic optimization of chemical reaction systems

V. Hatzimanikatis; G. Lyberatos; S. Pavlou

Chemical Engineering Science. 1993.

DOI : 10.1016/0009-2509(93)80144-F.